Repulsive axon guidance: Abelson and Enabled play opposing roles downstream of the Roundabout receptors

Article Abstract:

Research has been conducted on the Drosophila Roundabout, a member of the repulsive axon guidance receptor family. Results indicate that Abelson tyrosine kinase and its substrate Enabled play direct and opposing roles in Roundabout signal transduction.

United States, Canada, Statistical Data Included, Cellular signal transduction, Protein tyrosine kinase, Protein-tyrosine kinase, Cell receptors, Cell research, Cytological research

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Roundabout controls axon crossing of the CNS midline and defines a novel subfamily of evolutionary conserved guidance receptors

Article Abstract:

Research was conducted to describe the characterization and cloning of robo gene in Drosophila on the basis of Robo-like sequences in mammals. The southern blots of robo alleles and their parental chromosomes were determined with fragments from partial cDNA clones while DNA was obtained from homozygous mutant embryos. Results indicated that the nematode genome had only a single Robo family member and that the Robo protein was restricted to longitudinal axons.

Proteins, Axons, Mammals, Nematoda, Nematodes, Neural receptors

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Slit proteins bind Robo receptors and have an evolutionary conserved role in repulsive axon guidance

Article Abstract:

A Drosophila study using genetic analysis led to the identification of the slit protein as the primary ligand candidate for the repulsive guidance receptor Roundabout (Robo). The slit protein, which was expressed by cells at the midline of the Drosophila nervous systems, was observed to have high-affinity binding to Robo proteins. Its capacity to repel embryonic spinal motor axons was also noted.

Physiological aspects, Membrane proteins, Protein binding, Ligands (Biochemistry), Neurogenetics

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