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Protein tyrosine phosphatases in the human genome

Article Abstract:

Tyrosine phosphorylation is catalyzed by protein tyrosine kinases, which are represented by 90 genes in the human genome. The set of 107 genes in the human genome that encode members of the four protein tyrosine phosphatase (PTP) families is presented. The four families of PTPases, their substrates, structure, function, regulation, and the role of these enzymes in human disease are discussed.

Author: Hunter, Tony, Bottini, Nunzio, Godzik, Adam, Mustelin, Tomas, Alonso, Andres, Dixon, Jack, Sasin, Joanna, Friedberg, Ilan, Osterman, Andrei, Friedberg, Iddo
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2004
Human genetics, Genetic regulation, Protein tyrosine kinase, Protein-tyrosine kinase

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Indicted: Worms caught using steroids

Article Abstract:

Detailed genetic studies that provide new insights into endocrinology in the nematode worm Caenorhabditis elegans are previewed. The findings identify natural steroid ligands for the DAF-12 nuclear receptor, clarify that endocrine circuits regulate progression through the life cycle and aging in all higher organism from C. elegans up to human.

Author: Thummel, Carl S., Beckstead, Robert B.
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
United States, Genetic aspects, Caenorhabditis elegans, Cell receptors, Endocrinology

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