SNAP19 mediates the assembly of a functional core promoter complex (SNAPc) shared by RNA polymerases II and III

Article Abstract:

The transcription factor SNAPc binds to the proximal sequence element (PSE), which is a core part of the RNA polymerase II and III snRNA promoters for humans. SNAPc is made up of four or more subunits, but they have not been entirely identified for recombinant SNAPc. SNAPc has been reconstituted from five recombinant units, one of which is newly identified and called SNAP19. The recombinant complex binds specifically to the PSE. It controls RNA polymerase II and III snRNA gene transcription. The core SNAPc nucleates the assembly of two classes of initiation complexes.

Genetic regulation, Genetic recombination, Recombinant proteins

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The transcriptional activity of RNA polymerase I is a key determinant for the level of all ribosome components

Article Abstract:

A yeast strain is constructed expressing a Pol I that remains competent for initiation of transcription under stress conditions and it is demonstrated that depression of Pol I transcription leads to derepression of Pol II transcription, restricted to genes encoding ribosomal proteins. The results show that partial depression of Pol I activity drives abnormal accumulation of ribosomal components, highlighting critical role of regulation of Pol I activity within control of ribosome biogenesis.

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Does Po1 I talk to Po1 II? Coordination of RNA polymerases in ribosome biogenesis

Article Abstract:

A study examines whether a similar cross-talk between Pol I and Pol II transcription of ribosomal protein can be seen in mammalian cells. Results reveal that in such cells, the mechanism by which TOR regulates production of ribosomal proteins is at translation level, not transcription through S6 kinase and it is possible that mechanism linking Pol I transcription to Pol II transcription activity at ribosomal protein genes is conserved.

Health aspects, Rapamycin, Structure, Epigenetic inheritance

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