Searching chromatin for stem cell identity

Article Abstract:

Stem cells encapsulate the fundamental problem of metazoan biology in miniature, and increasing evidence indicates that stem cell chromatin activates proliferation genes and represses differentiation genes. Understanding how Polycomb group proteins stabilize these configurations will advance the understanding of embryonic development, tissue homeostasis, regeneration, aging and oncogenesis.

Stem cells, Oncogenes, Genetic research

---

Intergenic transcription through a polycomb group response element counteracts silencing

Article Abstract:

The switch from the silenced to the activated state of a polycomb group response element (PRE) is presented that requires noncoding transcription by using a transgenic reporter system. Results concluded that all other PREs corresponding target gene, suggesting that anti-selecting by transcription is a fundamental aspect of the cellular memory system.

United States

---

The Drosophila P68 RNA helicase regulates transcription deactivation by promoting RNA release from chromatin

Article Abstract:

The Drosophila homolog of the mammalian P68 RNA helicase is shown which plays a novel role in RNA export. Observations reveal a strong connection between transcript clearance and gene repression and P68 may be needed rapidly to move transcripts from a gene before its activity can be shut down and its chromatin reset to an inactive state.

RNA

Similar abstracts:

• Abstracts: A novel role for Xist RNA in the formation of a repressive nuclear compartment into which genes are recruited when silenced
• Abstracts: Sensors and signals: A coactivator/corepressor/epigenetic code for integrating signal-dependent programs of transcriptional response
• Abstracts: Development of a rapid method for simulataneous recovery of diverse mircobes in drinking water by ultrafiltration with sodium polyphosphate and surfactants
• Abstracts: Control of transcription through intragenic patterns of nucleosome composition. Coordinated remodeling of cellular metabolism during iron deficiency through targeted mRNA degradation
• Abstracts: Characterization of a large, stable, high-copy-number Streptomyces plasmid that requires stability and transfer functions for heterologous polyketide overproduction

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.