Sensors and signals: A coactivator/corepressor/epigenetic code for integrating signal-dependent programs of transcriptional response

Article Abstract:

The functional consequences of molecular sensor and molecular adaptor actions of corepressor/coactivator complexes in integrating signal dependent programs of transcriptional responses at the molecular level are reviewed. This strategy imposes a temporal order for modifying programs of transcriptional regulation in response to the cellular milieu, which is used to mediate developmental/homeostatic and pathological events.

Eukaryotes, Genetic transcription, Transcription (Genetics), DNA-ligand interactions, DNA binding

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Molecular determinants of crosstalk between nuclear receptors and toll-like receptors

Article Abstract:

Signal- and gene-specific repression of transcriptional responses initiated by engagement of toll-like receptors (TLR) 3,4, and 9 in macrophages is reported. The glucocorticoid receptor (GR) represses a large set of functionally related inflammatory response genes by disrupting p65/interferon regulatory factor (IRF) complexes required for TLR4- or TLR9-dependent, but not TLR3-dependent, transcriptional activation.

Biological Product (except Diagnostic) Manufacturing, Biological products exc. diagnostic, Interferon, Genetic aspects, Corticosteroids, Glucocorticoids

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Macrophage/cancer cell interactions mediate hormone resistance by a nuclear receptor derepression pathway

Article Abstract:

The occurrence of specific interactions between prostate cancer cells and macrophages in most prostate cancers is discussed. The interactions mediate a switch in function of selective androgen receptor antagonist/modulators (SARMs) as agonists and activate a functional program of specific proinflammatory signals causing dismissal of the N-CoR holocorepressor complex from AR.

Japan, Cancer cells, Homeostasis, Structure

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