Secretion of human serum albumin by Kluyveromyces lactis overexpressing KIPDII and KIEROI

Article Abstract:

The dosage of the genes was increased encoding the proteins in the yeast Kluyveromyces lactis and the secretion of heterologous proteins was evaluated. The results confirm that the endoplasmic reticulum oxidoreuction (ERO1) genes of Saccharomyces cerevisiae and Kluyveromyces lactis are functionally similar even though portions of their coding sequence are quite different and the phenotypes of mutants overexpressing the genes differ.

Biological Product (except Diagnostic) Manufacturing, Biological products exc. diagnostic, Blood Albumin, Physiological aspects, Genetic aspects, Endoplasmic reticulum, Yeast fungi, Yeasts (Fungi), Serum albumin, Nucleotide sequencing

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Inactivation of the KIPMR1 gene of Kluyveromyces lactis results in defective cell-wall morphogenesis

Article Abstract:

A study was conducted to analyze a unique involvement of KIPmr1p in cell-wall morphogenesis of Kluyveromyces lactis. Results indicated that the absence of KIPmr1p led to the accumulation of round, large cells supporting an abnormally thick cell wall. Findings also showed that the deletant strain featured a delocalized deposition of chitin in the lateral cell wall accompanied by an unbalanced ratio of insoluble to soluble glucans.

Cells (Biology), Cells, Morphogenesis, Calcium, Calcium (Chemical element), Glucans, Homeostasis

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Improved production of heterologous proteins by a glucose repression-defective mutant of kluyveromyces lactics

Article Abstract:

A study was conducted to examine the secreted production of heterogenous proteins in lkuyvermyces lactics. A glucoamylase (GAA) from the yeast of Arxula adenivinorans was used as a reporter protein for the study of the secretion efficiencies of several wild type and mutant strains of K. lactis.

Microbiology, Proteins, Amylases

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