Sex chromosome specialization and degeneration in mammals

Article Abstract:

The origin and organization of the human sex chromosomes and the degradation of the Y are explored, focusing on factors that might speed up or slow down degradation and the loss of Y and on the possible outcomes of loss of the Y. Mole voles and country rats provide evidence that a revolution in chromosomal sex need not herald the collapse of human reproduction since there are many ways in which a new sex-determining system could usurp the old without any changes being evident to humans.

Human genetics, Sex chromosomes

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A cell-surface receptor for lipocalin 24p3 selectively mediates apoptosis and iron uptake

Article Abstract:

The lipocalin mouse 24p3 is implicated in diverse physiological processes, including apoptosis due to interleukin-3(IL-3) deprivation and iron transport and hence the cloning of the 24p3 cell-surface receptor (24p3R) is reported. Results reveal an unanticipated role for intracellular iron regulation in an apoptotic pathway relevant to BCR-ABL-induced myeloproliferative disease and its treatment.

Cell receptors

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Electron transfer between cytochrome c and p66(super Shc) generates reactive oxygen species that trigger mitochondrial apoptosis

Article Abstract:

P66(super Shc) is a genetic determinant of life span in mammals, which regulates reactive oxygen species (ROS) metabolism and apoptosis. Study is conducted to show that P66(super Shc) is a redox enzyme that generates mitochondrial ROS as signaling molecules for apoptosis.

Cytochrome c

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