Slit is the midline repellent for the Robo receptor in Drosophila

Article Abstract:

Roundabout (Robo) is a repulsive guidance receptor on growth cones in Drosophila that binds to an unidentified midline ligand. A recent study using the Drosophila provided biochemical evidence that identified this unknown midline gland and labeled it slit. Slit was found to be an extracellular matrix protein that is produced by midline glia. Its function s are to act as a short-range repellent controlling axon crossing of the midline and as a long-range chemorepellent controlling mesoderm migration away from the midline.

Protein binding, Ligands (Biochemistry), Cell receptors

---

The transmembrane tyrosine phosphatase DLAR controls motor axon guidance in Drosophila

Article Abstract:

The significance of the Drosophila transmembrane protein-tyrosine phosphatase leukocyte common antigen-related (DLAR) in motor axon guidance was studied. Segmental nerve b motor axons in DLAR-deficient embryos, bypassed their muscle destinations. Findings indicated that DLAR regulates the capability of certain motor axons to find their way along certain choice points in the developing Drosophila nervous system.

Axons, Tyrosine

---

Crystal structure of the tandem phosphatase domains of RPTP LAR

Article Abstract:

A study was conducted to characterize the structure of the tandem phosphatase domains of receptor-like protein tyrosine phosphatases leukocyte antigen-related (RPTP LAR) proteins. Findings show that the tertiary structure of the LAR D1 and D2 conserved phosphatase domains are almost similar. Their only conformational difference is the presence of two amino acid in the D2 domain.

Analysis, Cell research, Cytological research, Tyrosine metabolism

Similar abstracts:

• Abstracts: Delineation of the critical deletion region for congenital heart defects, on chromosome 8p23.1. Renpenning syndrome maps to Xp11
• Abstracts: Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis. Mice lacking the CNTF receptor, unlike mice lacking CNTF, exhibit profound motor neuron deficits at birth
• Abstracts: Direct evidence for the involvement of extracellular proteins in the adhesion of Azospirillum brasilense. Glycosylation of the flagellin of the polar flagellum of Azospirillum brasilense, a gram-negative nitrogen-fixing bacterium
• Abstracts: Structure of the Clostridium stercorarium gene celY encoding the exo-1,4-beta-glucanase Avicelase II. Isolation and properties of acetate kinase- and phosphotransacetylase-negative mutants of Thermoanaerobacter thermohydrosulfuricus
• Abstracts: Stabilization of botulinum toxin type A during lyophilization. Genome analysis of Clostridium botulinum type A by pulsed-field gel electrophoresis

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.