Solution structure of anti-HIV-1 and anti-tumor protein MAP30: structural insights into its multiple functions

Article Abstract:

The structure of anti-tumor and anti-HIV-1 plant protein MAP30, a ribosome-inactivating protein, has been investigated and structural insights into multiple functions gained. MAP30 comes from Momordica charantia, bitter melon, the extracts of which have long been used as therapeutic agents. The protein is among the largest single-chain proteins the solution structures of which have been found without a prior X-ray crystal structure. It behaves as would a DNA glycosylase/apurinic lyase.

Statistical Data Included, Research, Analysis, HIV (Viruses), HIV, Enzymes, DNA damage, Ribosomes, Immunocytochemistry, Medicinal plants, Enzyme structure-activity relationships, Plant proteins, Virus inactivation

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Membrane type I matrix metalloproteinase usurps tumor growth control imposed by the three-dimensional extracellular matrix

Article Abstract:

Research reveals that the matrix metalloproteinase, MT1-MMP, facilitates three-dimensional growth of tumor cells in vitro and in vivo. Results suggest that MT1-MMP functions as a tumor-derived growth factor, which is involved in the regulation of cell proliferation by controlling cell geometry within a three-dimensional extracellular matrix.

Influence, Growth, Cellular control mechanisms, Cell regulation, Cancer cells, Cell proliferation, Metalloproteins, Company growth

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