Specificity and mechanism of the histone methyltransferase Pr-Set7

Article Abstract:

The crystal structure of a ternary complex of the enzyme Pr-Set7 that methylates Lys 20 of histone H4 [H4-K20] is presented. The results demonstrate that the enzyme is exclusively a mono-methylase and is therefore responsible for a signaling role quite distinct from that established by other enzymes that target this histone residue.

Restriction enzymes, DNA, DNA restriction enzymes, Methyltransferases, Genes

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Su(var) genes regulate the balance between euchromatin and heterochromatin in Drosophila

Article Abstract:

A major regulator of position-effect variegation (PEV), the heterochromatic SU(VAR)3-9 HMTase controls H3-K9 di-and trimethylation in Drosophila. Isolation of 19 point mutants demonstrates that the silencing potential of Su(var)3-9 increases with its associated HMTase activity.

Methods, Chromatin, Drosophila, Methylation

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