Structural basis for cooperativity in recruitment of MAML coactivators to notch transcription complexes

Article Abstract:

The crystal structure of a Notch transcriptional activation complex containing the ankyrin domain of human Notch1 (ANK), the transcription factor CSL on cognate DNA, and a polypeptide from the coactivator Mastermind-like-1 (MAML-1) is reported. The composite binding surface likely restricts the recruitment of MAML proteins to promoters on which Notch:CSL complexes are preassembled, ensuring tight transcriptional control of Notch target genes.

Human genetics, Crystals, Crystal structure

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Genome-wide high-resolution mapping and functional analysis of DNA methylation in Arabidopsis

Article Abstract:

The first comprehensive DNA methylation map of an entire genome, at 35 base pair resolution, using the flowering plant Arabidopsis thaliana as a model is reported. Whole-genome tiling-array transcriptional profiling of DNA methyltransferase null mutants identified hundreds of genes and intergenic noncoding RNAs with altered expression levels, many of which might be epigenetically controlled by DNA methylation.

Chromosome mapping, Arabidopsis

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Heritable integration of kDNA minicircle sequences from Trypanosoma cruzi into the Avian Genome: insights into human chagas disease

Article Abstract:

The genetic transfer of DNA between eukaryotes from different kingdoms is analyzed using the mitochondrial kinetoplast DNA (kDNA) of the intracellular parasite Trypanosoma cruzi transfer to human patients with Chagas disease. It is found that kDNA integration represents a potential cause for the autoimmune response that develops in a percentage of chronic Chagas patients.

Eukaryotes, Chagas' disease, Chagas disease

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