The structural basis for regulated assembly and function of the transcriptional activator NtrC

Article Abstract:

X-ray solution scattering and electron microscopy structures of the activated, full-length nitrogen regulatory protein C (NtrC) is reported, showing a novel mechanism for regulation of AAA+ ATPase assembly via the juxtaposition of the receiver domains and ATPase ring. Accompanying the hydrolysis cycle that is required for transcriptional activation, major order-disorder changes in the GAFTGA loops involved in the sigma(super 54) binding as well as in the DNA-binding domains are observed.

Science & research, Research, Genetic transcription, Transcription (Genetics), DNA-ligand interactions, DNA binding, Hydrolysis, Protein C, Chemical properties

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The species-specific egg receptor for sea urchin sperm adhesion is EBR1, a novel ADAMTS protein

Article Abstract:

Research has been conducted on species-specific egg bindin receptor from sea urchins. The authors describe the identification and characterization of this receptor, and they report that the recombinant species-specific egg bindin receptor and hyalin-like repeats are species-specific ligands for the sperm adhesive protein bindin.

Analysis, Genetic aspects, Proteins, Ligands (Biochemistry), Cell adhesion, Metalloproteins, Genetic research, Eggs (Biology), Spermatozoa, Sperm

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