Specificity in transforming growth factor--beta signaling pathways

Article Abstract:

Molecular embryogenesis and mechanisms by which signaling specificity can be achieved are reviewed using the frog Xenopus laevis as a model system. Experiments testing classic models of pattern formation in embryogenesis have been carried out using Xenopus. Bone morphogenetic proteins (BMPs) are involved in bone morphogenesis and embryonic patterning. That shows that transforming growth factor (TGF)-beta ligands can bring on differential responses depending on cell context. Questions about signaling specificity are central in the TGF-beta field.

United States, Genetic aspects, Cellular signal transduction, Morphogenesis, Transforming growth factors

---

Retinitis pigmentosa and progressive sensorineural hearing loss caused by a C12258A mutation in the mitochondrial MTTS2 gene

Article Abstract:

Studies have provided substantial evidence supporting the causative link between the C12258A mtDNA mutation and Usher's syndrome disorders. The disorders, characterized by hearing loss and retinitis pigmentosa-induced blindness, affect Irish kindred populations. The transversion discovered at position 12258 was heteroplasmic and found only in family members, a sequence change not observed in unaffected individuals.

Ireland, Health aspects, Genetic disorders, Hearing loss, Irish (European people), Irish, Retinitis pigmentosa, Usher's syndrome

---

Similar abstracts:

• Abstracts: Stage-specific induction of DNA methyltransferases in olfactory receptor neuron development. Characterization of loss-of-function and gain-of-function Eph receptor tyrosine kinase signaling in C. elegans axon targeting and cell migration
• Abstracts: Eighty years in the making. To build a killing machine. Juan Rivera
• Abstracts: Structure and dynamics of experimentally introduced and naturally occurring Laccaria sp. discrete genotypes in a Douglas fir plantation
• Abstracts: Transmitting genetic risk information in families: attitudes about disclosing the identity of relatives. Fetal DNA in maternal plasma: the plot thickens and the placental barrier thins

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.