Spleen versus pancreas: Strict control of organ interrelationship revealed by analyses of Bapx1(super -1-) mice

Article Abstract:

Pancreatic epithelial cells undergo morphological and molecular changes, including onset of markers for gut specific differentiation, whereas splenic mesenchyme transforms to constitute the adjacent smooth muscles in Bapx1-null mice. It is shown that during normal development Bapx1-dependent morphogenetic movement and tissue separation of pancreas-associated mescenchyme is key to facilitate spleen and pancreas formation.

United States, Science & research, Research, Growth, Epithelial cells, Genetic markers, Spleen, Company growth

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Opposing actions of Arx and Pax4 in endocrine pancreas development

Article Abstract:

Research has been conducted on Arx and Pax4 transcription factors which oppose each other in endocrine commitment. The authors suggest that these transcription factors' antagonistic functions for islet cell specification are related to the respective transcripts' pancreatic levels.

Denmark, France, Causes of, Polymerase chain reaction, Gene expression, Pancreas, Hypoglycemia, Endocrine gland diseases, Endocrine diseases

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Vax1, a novel homeobox-containing gene, directs development of the basal forebrain and visual system

Article Abstract:

Results show that Vax1 gene is expressed in developing basal forebrain and optic nerves and mutants lacking this gene exhibit dysgenesis in the components of the visual system. Molecular analysis reveal that absence of Vax1 interferes in the expression of Pax6 and Rx genes.

Statistical Data Included, Brain, Homeobox genes, Localization (Brain function), Optic nerve

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