Statistical tests of neutrality of mutations

Article Abstract:

The distribution of mutations in the genealogy of a random sample of genes from the population may be described as either external or internal, where the latter are the 'new' mutations while the former describe 'old' mutations. The statistical properties of the internal and external mutations are studied and their relationship to two commonly used algorithms to derive the expected number of external mutations are assessed. Statistical tests were also used to assess the neutrality of the mutations.

Evaluation, Genetic aspects, Mutation (Biology), Mutation, Genealogy

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Absence of BCL10 mutations in human malignant mesothelioma

Article Abstract:

A study was conducted to analyze BCL10 as a candidate for the 1p22 putative tumor suppressor gene in malignant mesotheliomas. The potential function of the gene in human malignancy was discussed. Fifty malignant mesotheliomas were examined for loss of heterozygosity. Results indicated that BCL10 is not mutated or abnormally expressed in malignant mesotheliomas. Findings also showed that the gene cannot be a candidate for the 1p22 tumor suppressor gene.

Lymphomas

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In response to Fakruddin et al. and Apostolou et al

Article Abstract:

Some of the results of studies conducted by J. Mohamed Fakruddin et al and S. Apostolou et al concerning the frequency and nature of BCL10 polymorphisms invite comment. Some BCL10 abnormalities may be found only in RNA and not genomic DNA. The authors failed to suggest that BCL10 may undergo posttranscriptional sequence modification. In addition, they failed to address discrepancies in data resulting from the posttranscriptional modification of BCL10.

Genetic polymorphisms

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