Structural and functional differences in two cyclic bacteriocins with the same sequences produced by lactobacilli

Article Abstract:

L. reuteri LA6 and lactobac illus gasseri LA39 isolated from feces of the sane human infant are found to produce similar cyclic bacteriocins that cannot b distinguished by molecular weights or primary amino acid sequences. The findings suggest that the different D-lanine contents of the bacteriocins may cause the differences in modes of action, amounts of potassium ion efflux and secondary structures.

Risk factors, Microbiology, Bacteriocins

---

Production of novel rapamycin analogs by precursor-directed biosynthesis

Article Abstract:

An investigation on the use of precursor-directed biosynthesis to create new rapamycin analogs by substitution of unusual L-pipecolate analogs in place of the normal amino acid is presented. The results suggest that the L-pipecolate analog (plusmn)-nipecotic acid inhibits the biosynthesis of L-pipecolate, thereby limiting the availability of this molecule for rapamycin biosynthesis.

Rapamycin

---

L-alanine auxotrophy of Lactobacillus johnsonii as demonstrated by physiological, genomic, and gene complementation approaches

Article Abstract:

A study using a chemically defined medium without L-alanine, Lactobacillus johnsonii is demonstrated to be strictly auxotrophic for that amino acid, is presented. A comparative genetic analysis showing that all known genes involved in L-alanine biosynthesis are absent from the genome of L. johnsonii, is also presented.

Genetic research

Similar abstracts:

• Abstracts: Strain-specific differences in the grazing sensitivities of closely related ultramicrobacteria affiliated with the Polynucleobacter cluster
• Abstracts: Power analysis for real-time PCR quantification of genes in activated sludge and analysis of the variability introduced by DNA extraction
• Abstracts: Genetic diversity and potential function of microbial symbionts associated with newly discovered species of Osedox polychaete Worms
• Abstracts: Structural basis for the histone chaperone activity of Asf1. Sus1, a functional component of the SAGA histone acetylase complex and the nuclear pore-associated mRNA export machinery
• Abstracts: Rapid quantitative detection of Listeria monocytogenes in meat products by real-time PCR. Quantitative detection of Listeria monocytogenes and Listeria innocua by real-time PCR: assessment of hly, iap, and lin02483 targets and Amplifluor technology

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.