Structurally related receptors and antagonists compete for secreted Wnt ligands

Article Abstract:

Wnts are signaling proteins expressed both in embryos and adults which function in intercellular communication by interacting with the Frizzled family of serpentine receptors. Frzb is a protein that has been documented to be structurally similar to the Wnt binding region of Frizzled. It has also been shown to bind a Wnt through which it inhibits the latter's signaling activity. Frzb and the Frizzled family members, both exhibiting binding affinity with Wnt, thus represent structurally related receptors and antagonists that compete for a single ligand.

Cellular signal transduction, Ligand binding (Biochemistry), Molecular genetics

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Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways

Article Abstract:

In Drosophila, the receptor Frizzled (Fz) mediates planar cell polarity (PCP). Dishevelled (Dsh) transduces. For Wingless (Wg) signaling Dsh is necessary and DFz2 may be a receptor. Dsh is drafted selectively to the membrane by Fz, as has been shown by use of a heterologous system. The selective recruitment sets up signaling specificity in the Wg and PCP signaling pathways.

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The balance between isoforms of the Prickle LIM domain protein is critical for planar polarity in Drosophila imaginal discs

Article Abstract:

The Drosophila Prickle LIM domain protein is discussed. Balance between isoforms of the protein is critical for planar polarity in imaginal discs. The polarity gene prickle (pk) encodes a protein with a triple LIM domain and a novel domain that is seen in human, mouse and Caenorgabditis elegans homologs now designate PET.

United Kingdom, Statistical Data Included, Cytoskeleton

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