Structure of a heterophilic adhesion complex between the human CD2 and CD58 (LFA-3) counterreceptors

Article Abstract:

A study was conducted to analyze the crystal structure of the heterophilic adhesion complex between the amino-terminal domains of human CD2 and CD58. Results indicated an asymmetric, orthogonal, face-to-face interaction involving the major beta sheets of the respective immunoglobulin-like domains. Findings also showed that charged amino acid side chains form hydrogen bonds and salt links at the interface during the virtual absence of hydrophobic forces.

Molecular dynamics, Hydrogen bonding, Hydrogen bonds, Lymphocytes

---

Mechanisms contributing to cell receptor signaling and assembly revealed by the solution structure of an ectodomain fragment of the CD3epsilongamma heterodimer

Article Abstract:

Solution structure of a heterodimeric CD3epsilongamma ectodomain complex, an integral component of the T cell receptor (TCR) and pre-TCR, reveals that TCR-based signal transduction is facilitated by an hydrophobic interphase between the two C2-set immunoglobulin-like domains and parallel pairing of the C-terminal beta-strands of the complex.

Physiological aspects, T cell antigen receptors, Cellular signal transduction

---

A novel peptide recognition mode revealed by the X-ray structure of a core U2AF(sup)35/U2AF(sup)65 heterodimer

Article Abstract:

Crystal structure of the human core U2 auxiliary factor heterodimer reveals an RNA recognition motif on the central domain and a polyproline segment that interact through tryptophan residues. Data indicate that the core U2 auxiliary factor heterodimer binds RNA.

Protein binding, RNA splicing

Similar abstracts:

• Abstracts: Transcriptional regulation of the Drosophila gene zen by competing Smad and Brinker inputs. Brinker is a sequence-specific transcriptional repressor in the Drosophila embryo
• Abstracts: Genomic relationships between Artemia franciscana and A. persimilis, inferred from chromocentre numbers. Low among-population genetic differentiation in Chinese bisexual Artemia populations
• Abstracts: Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase. Regulation of CLOCK and MOP4 by nuclear hormone receptors in the vasculature: a humoral mechanism to reset a peripheral clock

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.