Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase

Article Abstract:

SMRT, Sin3, and N-CoR establish protein-to-protein link between deacetylases and DNA-bound repressors hence, the term corepressors. These corepressors interact with each other and influence nuclear receptor to remodel chromatin structure without altering the regulatory complex through the help of hormone dependent adaptor HDAC. Transcriptional repression is achieved through regulation of chromatin structure resulting in an opposed cellular differentiation.

Models, Chromatin, Thyroid hormones, Steroid hormones, Steroid receptors

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Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein

Article Abstract:

Research demonstrates the role of inhibitor of acetyltransferases complex (INHAT) in blocking acetylation of histones by binding to histone and preventing access to acetyl transferase substrae. Data show that a multiprotein cellular complex inhibits the histone acetyltransferase activity of p300/CBP and PCAF.

Histones, Enzymes, Genetic regulation, Genetic transcription, Transcription (Genetics), Carcinogenesis, Enzyme regulation

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Regulation of CLOCK and MOP4 by nuclear hormone receptors in the vasculature: a humoral mechanism to reset a peripheral clock

Article Abstract:

Results reveal that the retinoid receptors interaction with circulating hormonal signals MOP4 and CLOCK causes retinoic acid phase shifts in Per2 mRNA and in the smooth muscle cells, leading to a nuclear receptor-mediated hormonal signaling for regulating a peripheral clock in the vasculature.

Blood vessels, Circadian rhythms, Physiological regulation, Biological control systems

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