Study of the bldG locus suggests that an anti-anti-sigma factor and an anti-sigma factor may be involved in Streptomyces coelicolor antibiotic production and sporulation

Article Abstract:

The bldG gene is not involved in the regulation of antibiotic production and sporulation in Streptomyces coelicolor. A DNA fragment that can induce antibiotic production in a bldG mutant codes for a protein similar to the anti-anti-sigma factors of Bacillus and Staphylococcus.

Canada, Antibiotics

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The bldA-encoded tRNA is poorly expressed in the bldl mutant of Streptomyces coelicolor A3(2)

Article Abstract:

Streptomyces spp. have many metabolites which are medically important antibiotics and have therefore been the focus of much study. The bld mutants are usually blocked in antibiotic production but understanding such mutants can help to understand other regulatory signals. It has been shown, for instance, that the bldA-encoded RNA accumulates late in the process at a time which would indicate a regulatory role in morphological differentiation and antibiotic production.

Gene expression

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Association of early sporulation genes with suggested developmental decision points in Streptomyces coelicolor A3(2)

Article Abstract:

Early sporulation genes and association with suggested developmental decision points in Streptomyces coelicolor A3(2) are discussed. New information about the role of whiF (ital) has been found through cytological analysis of a series of mutants. Knowledge about whiG, whiA and whiB (all ital) has been confirmed and extended. A model explains the mutant phenotypes proposing two early developmental decision points related to commitment to sporulation septation.

Statistical Data Included, Usage, Genetic aspects, Spores (Bacteria), Bacterial spores, Cytochemistry, Chromosome mapping, Cell division

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