Maternal IL-11R-alpha function is required for normal decidua and fetoplacental development in mice

Article Abstract:

In eutherian mammals, the chorioallantoic placenta maternal-fetal interface is necessary for embryo survival/development. IL-11R-alpha signaling at the implantation site seems to be necessary for decidua development. The decidua, the function of which is little understood, encloses the conceptus and makes up the maternal portion of the placenta. The receptor for interleukin-11, a cytokine, is needed for normal establishment of the decidua.

Proteins, Placenta, Cell receptors, Mammals, Animal reproduction

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A mechanism of repression of TGFB/Smad signaling by oncogenic Ras

Article Abstract:

Hyperactive oncogenic Ras can repress antimitogenic TGFB functions in cancer cells. This is achieved by the negative regulation of TGFB mediators Smad2 and Smad3, inhibiting their nuclear accumulation. Ras causes phosphorylation of the TGFB mediators at the DNA-binding and transcriptional activation domain links. the growth inhibitory response in Ras-transformed cells can be achieved through mutations of Smad3.

United States, Tumor suppressor genes, Ras genes

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