TRF1 is degraded by ubiquitin-mediated proteolysis after release from telomeres

Article Abstract:

Research has been conducted on DNA-binding protein TRF1 which is telomere length's negative regulator. The authors demonstrate that the loss of TRF1 from telomeres leads to degradation and ubiquitination of TRF1 by proteasome, and that the degradation is important for keeping TRF1 off telomeres.

Telomeres, Biodegradation, DNA binding proteins, Proteolysis, Ubiquitin

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How does calorie restriction work?

Article Abstract:

The authors review the publications on calorie restriction. The topics of interest include the role of calorie restriction in aging mechanism, and yeast replicative life span regulation by calorie restriction.

Calories, Aging

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Protein ISGylation modulates the JAK-STAT signaling pathway

Article Abstract:

Research has been conducted on protease removing ISG15 from ISGylated proteins. The authors demonstrate that the mice lacking this protease are hypersensitive to type I interferon.

Biological Product (except Diagnostic) Manufacturing, Biological products exc. diagnostic, Interferon, Cells (Biology), Proteases, Proteins, Cells

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