Target hub proteins serve as master regulators of development in yeast

Article Abstract:

An investigation of the transcriptional circuitry controlling pseudohyphal development in Saccharomyces cerevisiae to understand the organization of the transcriptional networks that govern cell differentiation is presented. Target hubs can serve as master regulators whose activity is sufficient for the induction of complex developmental responses and therefore represent important regulatory nodes in biological networks.

Food preparations, not elsewhere classified, All Other Miscellaneous Food Manufacturing, Brewers' Yeast, Genetic aspects, Eukaryotes, Yeast fungi, Yeasts (Fungi), Brewer's yeast, Saccharomyces cerevisiae

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Global changes in STAT target selection and transcription regulation upon interferon treatments

Article Abstract:

The regions of human chromosome 22 bound by Single Transducers and Activators of Transcription (STAT)1 and STAT2 in interferon-treated cells are identified using chromatin immunoprecipitation and DNA microarray analysis. Results demonstrate that the DNA-binding behavior of STAT1 homodimers is not conserved between the different interferon treatment conditions.

Electronic components, not elsewhere classified, Other Electronic Component Manufacturing, Transducers, Genetic research, DNA-ligand interactions, DNA binding, Human chromosomes

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