Tectonic, a novel regulator of the Hedgehog pathway required for both activation and inhibition

Article Abstract:

The identification of a novel protein that participates in Hedgehog (Hh)-mediated patterning of the neutral tube is reported. Characterization of Tectonic Sonic hedgehog and Tectonic Smoothened double mutations indicates that Tectonic plays an additional role in repressing Hh pathway activity.

United States, Gene mutations, Gene mutation

---

Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates

Article Abstract:

A study on the role of Hedgehog(Hh) signaling in multiple aspects of embryonic development is conducted. The results reveal that Hh palmitoylation is essential for generation of a soluble multimeric protein complex, which constitutes the major active component for Hh signaling.

Proteins, Vertebrates

---

Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordia

Article Abstract:

Hh signaling in NCC is crucial for normal patterning and growth of the face. Fox genes mediate the action of shh in facial development.

Similar abstracts:

• Abstracts: Negative regulation of the Wee1 protein kinase by direct action of the Nim1/Cdr1 mitotic inducer. The Xenopus Cdc6 protein is essential for the initiation of a single round of DNA replication in cell-free extracts
• Abstracts: Net1, a Sir2-associated nucleolar protein required for rDNA silencing and nucleolar integrity. Evolution of a combinatorial
• Abstracts: Assessment of the effectiveness of low-pressure UV light for inactivation of Helicobacter pylori. Survival of Helicobacter pylori in a natural freshwater environment
• Abstracts: Txr1: A transcriptional regulator of thrombospondin-1 that modulates cellular sensitivity to taxanes. Conserved mechanisms across development and tumorigenesis revealed by a mouse development perspective of human cancers

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.