Txr1: A transcriptional regulator of thrombospondin-1 that modulates cellular sensitivity to taxanes

Article Abstract:

The txr1, identified by DNA sequence, as putative protein of unknown function is shown as a transcriptionally down-regulating expression of anti-angiogenic and proapoptotic glycoprotein thrombospondin-1. The results show that trx1is a regulator of thrombospondin-1, mediated cell functions and suggest a potential approach for therapeutic modulation of these functions as well as potentiation of taxol effects.

Health aspects, Analysis, Genetic aspects, Glycoproteins, Neovascularization, Nucleotide sequencing

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Foxm1b transcription factor is essential for development of hepatocellular carcinomas and is negatively regulated by the p19(super ARF) tumor suppressor

Article Abstract:

The leading cause of cancer-related deaths-hepatocellular carcinoma (HCC) in relation with Forkhead Box m1b (Foxm1b) transcription factor is studied. The experiments reveal that Foxm1b transcription factor is required for proliferative expansion and constitutes a potential target for human HCC tumor therapy to reduce spread of liver cancer.

Hepatoma, Hepatocellular carcinoma

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Conserved mechanisms across development and tumorigenesis revealed by a mouse development perspective of human cancers

Article Abstract:

A study on identification of common mechanism underlying organ development and primary tumor formation, using novel method, is conducted. Findings indicate that common programs underlie development and tumorigenesis.

Tumors, Tumours

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