Tel/Etv6 is an essential and selective regulator of adult hematopoietic stem cell survival

Article Abstract:

The Ets-related transcription factor Tel/Etv6, the product of a locus frequently involved in translocation in leukemia, a selective regulator of HSC survival is studied. Tel/Etv6 is a selective and essential regulator of postembryonic HSCs and the absence of Tel/Etv6after lineage commitment is ostensibly without consequence except for unexpected impairment of maturation of megakaryocytes

Genetic transcription, Transcription (Genetics), Leukemia

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Proplatelet formation of megakaryocytes is triggered by autocrine-synthesized estradiol

Article Abstract:

The megakaryocyte/erythrocyte-specific transcription factor, p45 NF-E2, is essential for initiating proplatelet formation (PPF). The estradiol synthesized in megakaryocytes that triggers PPF is reported. It is concluded that autocrine estradiol action regulates platelet production by triggering PPF.

Autocrine mechanisms, Genetic research, Estradiol

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Bone marrow-derived endothelial progenitor cells are a major determinant of nascent tumor neovascularization

Article Abstract:

The study was done on bone marrow-derived endothelial cells and the ability of tumor cells to develop new blood vessels in the earliest stages.

Endothelium, Cancer cells

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