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The BRCA1/BARD1 heterodimer modulates Ran-development mitotic spindle assembly

Article Abstract:

BRCA1/BARD1 is needed for mitotic spindle-pole assembly and for accumulation of TPX2, a major spindle organizer and Ran target, on spindle poles in both mammalian cells and Xenopus egg extracts. The studies have revealed a previously unrecognized function of BRCA1/BARD1 in mitotic spindle assembly that might contribute to its role in chromosome stability control and tumor suppression.

Author: Livingston, David M., Walter, Johannes C., Joukov, Vladimir, Groen, Aaron C., Prokhorova, Tatyana, Gerson, Ruth, White, Erinn, Rodriguez, Alison
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
Ubiquitin

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A mitotic role for BRCA1/BARD1 in tumor suppression?

Article Abstract:

Xenopus egg extracts are used to dissect the mitotic function of the tumor-suppressor protein BRCA1/BARD1 heterodimer. The study has provided evidence that BRCA1/BARD1 has a distinct role in mitosis therefore the loss of mitotic spindle assembly, a process conducted by the GTPase-Ran, might contribute to tumorigenesis.

Author: Clarke, Paul R., Sanderson, Helen S.
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2006
Guanosine triphosphatase, GTPases

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Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes

Article Abstract:

DNA damage-specific interactions were observed between BRCA1/BARD1 and the DNA damage-response proteins, TopBP1 and Mre11/Rad50/NBS1. The results support a new, multifactorial model that describes how genotoxic stress enables BRCA1 to execute a diverse set of DNA damage-response functions.

Author: Livingston, David M., Nakatani, Yoshihiro, Greenberg, Roger A., Sobhian, Bijan, Pathania, Shailja, Cantor, Sharon B.
Publisher: Cold Spring Harbor Laboratory Press
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2006
United States, DNA damage

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Subjects list: Research, Tumor suppressor genes, Structure, Tumour suppressor genes, BRCA mutations, Report
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