Think globally, act locally: the making of a mouse mammary gland

Article Abstract:

Since it has been possible to remove genes from the mouse genome it has been possible to identify genetic influences on mammary gland development. Using experimental manipulations of tissues from wild-type and knockout mice has enabled investigators to gain insight. Two developmental concepts have emerged, one related to the discrete signaling networks turned on by systemic endocrine hormones to bring on mammopoiesis and the other signals' being relayed through reciprocal interactions between epithelium and stroma. Knockout mice led to tools to identify the tissue compartment that gets and carries out signals.

Genetic regulation, Endocrinology, Experimental

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The C/EBP-beta transcription factor regulates epithelial cell proliferation and differentiation in the mammary gland

Article Abstract:

Ovarian and mammary gland transplants were performed with C/EBP-beta (CCAAT-enhancer binding protein) deficient mice. C/EBP-beta-deficient epithelium development was defective in a wild-type stroma and host background. C/EBP-beta is cell-autonomous in its role in the proliferation and differentiation of mammary secretory epithelial cells. It plays an essential role in activating milk protein genes.

Epithelial cells, Cell differentiation, Cell proliferation, Milk proteins

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