The C. elegans spe-9 gene encodes a sperm transmembrane protein that contains EGF-like repeats and is required for fertilization

Article Abstract:

A study was done to describe the phenotypic and molecular characterization of the mutant spe-9 gene in the nematode worm C. elegans. This gene encodes a sperm transmembrane protein with an extracellular domain that contains EGF-like repeats which involved in extracellular functions such as adhesive and ligand-receptor interactions. The overall structure of the predicted mutant phenotype SPE-9 protein is similar to that of ligands for the Notch/LIN-12/GLP-1 transmembrane receptors. Results suggest that SPE-9 functions in specialized cell-cell interactions required for fertilization.

Analysis, Membrane proteins, Spermatozoa, Sperm

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The VAB-1 Eph receptor tyrosine kinase functions in neural and epithelial morphogenesis in C. elegans

Article Abstract:

Research was conducted to characterize genes associated with epidermal morphogenesis in Caenorhabditis elegans. Vab-1 mutants were isolated based on their morphogenetic defects in head epidermis while sequences of genomic DNAs from the mutants were amplified. Results showed that the null phenotype of vab-1 has a variable defect in epidermal morphogenesis. They also indicated that signaling through receptors and ligands was correlated in axon guidance and topographic mapping.

Research, Gene mutations, Gene mutation, Morphogenesis

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A gene-centered C. elegans protein-DNA interaction network

Article Abstract:

A study employed 'gene-centered' high-throughput yeast one-hybrid (Y1H) assays to identify 283 interactions between 72 Caenorhabditis elegans digestive tract gene promoters and 117 proteins. The resulting protein-deoxyribonucleic acid interaction (PDI) network is highly connected and enriched for transcription factors (TFs) that are expressed in the digestive tract.

Yeast fungi, Yeasts (Fungi), Genetic research

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