The Drosophila Brahma complex is an essential coactivator for the trithorax group protein Zeste

Article Abstract:

Recent research has shown that the Drosophila Brahma chromatin-remodeling complex is required as a coactivator for the trithorax group (trxG) protein Zeste. Requirements for transcriptional activation by the Drosophila trG protein Zeste, DNA-binding activator of homeotic genes, have been studied. Distinction between general chromatin restructuring and transcriptional coactivation by remodelers were found. Novel insights into targeting mechanisms of different chromatin remodeling factors were found.

Israel, Netherlands, Chromatin, DNA binding proteins

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Amphiphysin is necessary for organization of the excitation-contraction coupling machinery of muscles, but not for synaptic vesicle endocytosis in Drosophila

Article Abstract:

Amphiphysin has been found to required in Drosophila for excitation-contraction coupling mechanisms of muscles, but not for synaptic vesicle endocytosis. To study amphiphysin the only gene for the protein was disrupted. Flies with no amphiphysin are viable with little or no detectable defect in synaptic vesicle endocytosis, but they cannot fly.

Physiological aspects, Muscle contraction

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Functional antagonism between E2F family members

Article Abstract:

E2F-control of cell proliferation comes from the interactions between two types of E2F complexes with opposing activities, with antagonism. In Drosophila development dEfG2 is a physiological partner for dDP and RBF and dE2F2 is an antagonist to dE2F1.

Genetic transcription, Transcription (Genetics), Cell cycle

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