The Drosophila Toll gene functions zygotically and is necessary for proper motoneuron and muscle development

Article Abstract:

A study was conducted to examine the expression of the Toll protein in late embryonic development in the nervous system and somatic musculature. Examination of toll mutants revealed that loss of one or both Toll genes leads to errant embryonic dorsal-ventral patterning, resulting to abnormal motoneuron number and muscle pattern. Meanwhile, denervation in the mutants results to collateral sprouting of nerve branches and ectopic placement of nerve endings. These results suggest that Toll genes play a key role in neuron and muscle development.

Genetic aspects, Muscles, Nervous system, Muscle proteins

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Expression of the Drosophila gooseberry locus defines a subset of neuroblast lineages in the central nervous system

Article Abstract:

Examination of the Drosophila gooseberry gene expression (gsb) in neuroblasts and their descendants in the central nervous system by utilizing the FLP recombinase of yeast as a marking systemshows that expression of the gsb-p protein occurs in a lineage-specific manner which is consistent with the activity of a selector gene. The gsb-p-expressing lineages have been traced and a map has been developed in which the neuronal descendants within the lineages have been defined.

Central nervous system, Developmental neurology

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