The LIN-2/LIN-7/LIN-10 complex mediates basolateral membrane localization of the C. elegans EGF receptor LET-23 in vulval epithelial cells

Article Abstract:

LIN-7 binds to LET-23 receptor tyrosine kinase (RTK) in vivo. This binding is required for LET-23 basolateral localization and for vulval induction. LIN-2 and LIN-10 form a protein complex with LIN-7, showing that all three proteins are directly involved in basolateral localization of LET-23 RTK. It has been possible to identify a mechanism for basolateral localization of the LET-23 RTK in C. elegans vulval epithelia. A similar mechanism could be involved in basolateral localization of other transmembrane proteins in polarized epithelial cells in all animals.

Epithelial cells

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LET-23 receptor localization by the cell junction protein LIN-7 during C. elegans vulval induction

Article Abstract:

LIN-7, a cell junction-associated protein, is required for the proper localization of LET-23 receptor tyrosine kinase to epithelial precursor (Pn.p) cell junctions during C. elegans vulval induction. LET-23 normally colocalizes with LIN-7 at the basal side of the cell junctions in Pn.p cells and LET-23 is mislocalized in lin-7 and lin-2 mutants. Proper localization of LET-23 appears to be required for LET-23 signaling activity, as lin-7 and lin-2 mutants exhibit a vulvaless phenotype.

Cell junctions

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MAP kinase signaling specificity mediated by the LIN-1 Ets/LIN-31 WH transcription factor complex during C. elegans vulval induction

Article Abstract:

Vulval development in Caenorhabditis elegans is mediated by the protein LIN-31. If this protein is bound by LIN-1, the resulting complex inhibits vulval induction. Phosphorylation of LIN-31 by a membrane-associated protein (MAP) kinase liberates it from its complex with LIN-1 and relieves the genetic repression. LIN-31 phosphorylation is also important for the differentiation of cells destined to become the vulva. The expression of both LIN-1 and LIN-31 is under the control of MPK-1.

Growth, Cell differentiation, Morphogenesis

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