The PKS4 gene of Fusarium graminearum is essential for zearalenone production

Article Abstract:

Zearalenones (ZON) are produced by several Fusarium species causing reproductive problems in animals and some of them produce elevated levels of ZON, one of the estrogenic mycotoxins comprising the zearalenones. An analysis of transcripts from polyketide synthase genes identified in the Fusarium graminearum database is carried out for these mutants and PKS4 is the only gene with an enoyl reductase domain that has a higher level of transcription in the aurofusarin mutants than in the wild type.

Polyketides

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Role of zearalenone lactonase in protection of Gliocladium roseum from fungitoxic effects of the mycotoxin zearalenone

Article Abstract:

The growth inhibition of filamentous fungi by zearalenone and the effect of disruption of the zes2 gene of Gliocladium roseum on the ability of the fungus to hydrolyze zearalenone and the resistance of Gliocladium roseum to zearalenone are evaluated. A biological function is suggested for zearalenone production and an ecological role for this fungal metabolite in a nonagricultural background.

Science & research, Research, Lactones, Report

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Mutational analysis of endoxylanases XylA and XylB from the phytopahtogen Fusarium graminearum reveals comprehensive insights into their inhibitor insensitivity

Article Abstract:

An extensive mutational study of Fusarium graminearum enzymes is performed to understand the surprising XIP-type endoxylanase inhibitor insensitivity of endoxylanases XylA and XylB from the phytopathogen Fusarium graminearum. It indicates a more specific interference with key enzymes in plant carbohydrate degradation upon pathogen attack.

Analysis, Gene mutations, Gene mutation, Biodegradation

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