The S. cerevisiae SAGA complex functions in vivo as a coactivator for transcriptional activation by Ga14

Article Abstract:

The Saccharomyces cerevisiae SAGA (Spt-Ada-Gen5-Acetyltransferase) complex has been found to act as a coactivator for transcriptional activation by Ga14 in vivo. Ga14-NP16 was also found to recruit SAGA in vivo. A specific interaction between Spt3 and TBP in vivo appears to be important for Ga14 transcriptional activation after SAGA recruitment. SAGA is a large multiprotein complex needed for normal transcription of many genes.

Saccharomyces

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Activation of dormant origins of DNA replication in budding yeast

Article Abstract:

Activation of dormant origins of DNA replication is discussed relative to budding yeast. It is shown that dormant replication origins on the left arm of budding yeast chromosome III are activated when two things happen. Both passive replication through them must be prevented and the Mec1/Rad53 checkpoint that blocks late-origin firing must be inactivated.

Genetic aspects, DNA, Physiological regulation, Biological control systems

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Binding of transcriptional activators to sigma 54 in the presence of the transition state analog ADP-aluminum fluoride: insights into activator mechanochemical action

Article Abstract:

Binding of transcriptional activators to sigma 54 in the presence of the transition state analog ADP-aluminum fluoride is discussed with attention to insights into activator mechanochemical action. Energy transduction seems to occur through activator contacts of sigma 54 Region I.

Mexico, Adenosine triphosphate, ATP, Aluminum compounds, Mechanical chemistry, Mechanochemistry

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