Sir2 links chromatin silencing, metabolism, and aging

Article Abstract:

Research has shown that Sir2 links chromatin silencing, metabolism, and aging according to this perspective article. It is unlikely, it seems, that a significant life span extension is on the horizon, but compressing the morbidity period using some kind of therapeutic may be feasible.

Chromatin, Metabolism, Suppression, Genetic, Suppressor mutation (Molecular genetics)

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Sip2p and its partner Snf1p kinase affect aging in S. cerevisiae

Article Abstract:

Sip2p and Snf1p kinase affect aging in Saccharomyces cerevisiae. It has been shown that deletion of the N-myristoylprotein, Sip2p, reduces resistance to nutrient deprivation and shortens the lifespan in S. cerevisiae through accelerated aging. The fast aging is seen in nucleolar fragmentation, loss of silencing from telomeres and mating loci, and accumulation of extrachromosomal rDNA. Ability to endure nutrient deprivation periods correlates directly with lifespan in many organisms. The change seen in glucose metabolism in the recent study discussed here is a new correlate of aging in yeast. It happens more and at earlier generational ages in sip2(Delta) cells.

Statistical Data Included, Energy metabolism, Bioenergetics, Protein kinases, Glucose, Cell physiology

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The SIR2/3/4 complex and 2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

Article Abstract:

The silent information regulator (SIR) genes defined as negative regulators of yeast aging in Saccharomyces cerevisiae are the focus of the article. The possibility that an alteration in SIR2p activity may alter the pace of aging in many organisms is discussed.

Analysis, Gene mutations, Gene mutation, Proteins, Molecular biology, Yeast, Yeast (Food product)

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