The SMN-SIP1 complex has an essential role in spliceosomal snRNP biogenesis

Article Abstract:

Spinal muscular atrophy (SMA), a fatal neuro-muscular disease, has been linked to the protein product of the Survival of Motor Neurons (SMN) gene. SMN is closely linked with SIP1, a novel protein, together forming a complex with spliceosomal snRNP proteins. The SMN-SIP1 complex was found to be linked with spliceeosomal snRNAs U1 an dU4 in the Xenopus oocytes cytoplasm. SMN-SIP1 antibodies, showing that the complex has direct involvement in the biogenesis of spliceosomal snRNPs.

Research, Observations, Proteins, RNA splicing, Spinal muscular atrophy

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From glycogen to amylopectin: a model for the biogenesis of the plant starch granule

Article Abstract:

Previous research has failed to identify the biochemical reactions responsible for the synthesis of an ordered crystalline starch structure. However, based on amylopectin structure and synthesis, a model that explains the biogenesis of the plant starch granule is presented. The model is consistent with the two-dimensional structures found in amylopectin clusters and allows the three-dimensional pattern of granule growth to be predicted.

Models, Starch, Biosynthesis

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Serotonylation of small GTPases is a signal transduction pathway that triggers platelet alpha-granule release

Article Abstract:

Research demonstrates the dependence of platelet alpha-granule secretion on cytoplasmic serotonin and calcium followed by transamidation of serotonin to small GTPases. This constitutes a receptor-independent intracellular signaling pathway, "serotonylation", for serotonin and is involved in alpha-granule exocytosis from platelets.

Germany, Analysis, Physiological aspects, Cellular signal transduction, Secretion, Serotoninergic mechanisms, Blood platelets

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