Messenger RNAs are recruited for nuclear export during transcription

Article Abstract:

Messenger RNAs (mRNAs) have been found to be recruited for nuclear export during transcription. In studying Np13 and mRNA export, mutations in Np13 and TATA-binding protein, combined, block mRNA export.

Chromatin

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Uncoupling of the hnRNP Np13p from mRNAs during the stress-induced block in mRNA export

Article Abstract:

Uncoupling of the hnRNP Np13p, the main mRNA-binding protein of Saccharomyces cerevisiae, from mRNAs in stress-induced inhibition of mRNA export is discussed. Data that point to an export-incompetent RNP complex without Np13p as the reason for constituitively exported mRNAs' not leaving the nucleus in stressed cells are presented based on seeing that Np13p is exported from the nucleus after onset of strees while mRNA stays nuclear.

Stress (Physiology), Genetic regulation, Physiological regulation, Biological control systems

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The Spt componenet of SAGA facilitate TBP binding to a promoter at a post-activator-binding step in vivo

Article Abstract:

Results of recent study of a coactivator role for PSpt3 and Spt20 in the recruitment of TBP are discussed. The Spt components of SAGA aid TBP binding to a promoter at a post-activator-binding step in vivo. Both Spt3 and Spt20 are necessary for the binding of TAT-binding protein, but not of the activator Gal4. That role is Gcn-5 independent.

Enzymes, Binding sites (Biochemistry), Active sites (Biochemistry)

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