Long palindromes formed in Streptomyces by nonrecombinational intra-strand annealing

Article Abstract:

Long-palindrome linear plasmids have been found to be formed in Streptomyces after double-strand breakage by a nonrecombinational intra-strand annealing that also involves inverted repeats (IRs). Long-palindrome formation takes place through unimolecular intrastrand annealing of IRs before 3' extension of the resulting DNA fold-back. It seems long-palindrome formation in Streptomyces may be generally applicable, a mechanism for generating DNA palindromes, long inverted repeat sequences.

DNA damage

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Terminal proteins essential for the replication of linear plasmids and chromosomes in Streptomyces

Article Abstract:

Tpg proteins have been seen, contrary to expectation, to contain a reverse transcriptase-like domain, not sequences in common with proteins that attach covalently to the termini of linear DNA replicons. Protein attached to the end of the pSLA2 linear plasmid of Streptomyces rochei has been purified, then the N-terminal amino acid sequence was determined and the information used to clone corresponding genes from an S. rochei cosmid library.

Genetic aspects, DNA, Circular DNA, Microbiological chemistry

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Recruitment of terminal protein to the ends of Streptomyces linear plasmids and chromosomes by a novel telomere-binding protein essential for linear DNA replication

Article Abstract:

Recruitment of terminal protein to the ends of Streptomyces linear plasmids and chromosomes by a novel telomere-binding protein have been found to be essential for linear DNA replication. The essential role of a novel 80-kD DNA bin ding protein (telomere-associated protein, Tap ) has been shown. Tap seems to recruit and position Tpg at the telomeres of repli cation intermediates.

Science & research, Carrier proteins, Transport proteins

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