The Vestigial and Scalloped proteins act together to directly regulate wing-specific gene expression in Drosophila

Article Abstract:

In Drosophila the gene 'vestigial' is necessary for wing formation. It can induce wing-like growths on other structures. Vestigial, the nuclear protein, must have the function of the Scalloped protein to activate directly expression of genes that are related to wing morphogenesis. Scalloped is a member of the TEA family of transcription regulators. Analyses, both genetic and molecular, show Vestigial regulates wing identity by making a complex with Scalloped. The complex binds sequence to essential sites specifically in wing-specific enhancers. Likely combinatorial regulation by selector proteins and signal transducers is a general feature of the tissue-specific control of gene expression in organogenesis.

South Korea, Genetic aspects, Observations, Cellular signal transduction, Cell differentiation, Cellular control mechanisms, Cell regulation, Drosophila, Transduction, Transduction (Genetics)

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ORC localization in 'Drosophila' follicle cells and the effects of mutations in dE2F and dDp

Article Abstract:

Research on Drosophila indicates that E2F controls several processes in DNA binding impacted by mutation. In the dE2F and dDP DNA-binding domains, mutations reduce amplification, affecting specific ORC2 localization by losing its amplification loci. Heterodimer subunit mutations support the pivotal role of E2F in initiating S phase and S phase activity.

Research, Gene mutations, Gene mutation, Proteins, DNA binding proteins, Gene amplification

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