The Wilms tumor suppressor WT1 (ital) encodes a transcriptional activator of amphiregulin (ital)

Article Abstract:

The Wilms tumor suppressor WT1 (ital), which encodes a transcriptional activator of amphiregulin (ital), is discussed. WT1 (ital) codes for a zinc finger transcription factor likely to be a factor in kidney tumorigenesis and differentiation. Hybridization to high-density oligonucleotide arrays was used to look for native genes, the expression of which is altered after inducible expression of WT1 (ital).

Research, Kidneys, Genetic transcription, Transcription (Genetics), Cell differentiation, Epidermal growth factor, Epidermal growth factors, Kidney, Nephroblastoma

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DOCK4, a GTPase activator, is disrupted during tumorigenesis

Article Abstract:

Research demonstrates that DOCK4 encodes a CDM family protein, which activates Rap GTPase. The DOCK4 regulates intercellular junctions and gets disrupted during tumorigenesis. Data indicate that expression of a wild-type DOCK4 in mouse osteosarcoma cells, containing a endogenous gene deletion, suppresses growth and tumor metastasis.

Cellular control mechanisms, Cell regulation, Metastasis, Cancer metastasis, Enzyme activation

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Identification of a DNA-binding site and transcriptional target for the EWS-WT1(+KTS) oncoprotein

Article Abstract:

Research has been conducted on endogenous gene up-regulated after inducible EWS-WT1(+KTS) expression in cancer cell lines. The authors have identified this gene via the use of cDNA substractive hybridization.

Analysis, Gene expression, Cancer cells, DNA binding proteins, Oncogenes, Genetic research

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