The carboxyl terminus of phage HK022 Nun includes a novel zinc-binding motif and a tryptophan required for transcription termination

Article Abstract:

The carboxyl terminus of phage HK022 Nun has been found to have a novel zinc-binding motif and a tryptophan required for transcription termination. The role of certain amino acid residues in the carboxy-terminal domain in transcription termination have been studied by NMR spectroscopy, by in vitro and in vivo functional assays, and by mutagenesis. Inhibition of BOXB binding was studied.

Bacteriophages, DNA binding proteins, Histidine

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Bromodomain factor 1 corresponds to a missing piece of yeast TFIID

Article Abstract:

Two proteins, Bromodomain factor 1 (Bdf1) and its homolog (Bdf2), have been isolated in studying the functions of TAFs and TFIID, a basal transcription factor, using a yeast two-hybrid screen. TFIID comprises TATA-binding protein (TBP) and 10-12 TBP-associated factors (TAFs). Bdf1 seems to correspond to the carboxy-terminal region of higher eukaryotic TAF(sub.II) 250. It appears the interaction between TFIID and Bdf1 is important for gene expression that is proper.

Gene expression, Yeast, Yeast (Food product), Protein kinases

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Ro ribonucleoproteins contribute to the resistance of Deinococcus radiodurans to ultraviolet irradiation

Article Abstract:

Study of the genome of the radiation-resistant eubacterium Deinococcus radiodurans is discussed in this research communication. The genome comprises an ortholog of an RNA-binding protein, Ro60-kD autoantigen, previously identified only in higher eukaryotes. It was found that Ro ribonucleoproteins are a factor in UV resistance in D. radiodurans.

Radiation, Radiation (Physics), Nucleoproteins, Eukaryotic cells, Cells (Biology), Eukaryotes

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