The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome

Article Abstract:

Research has been conducted on human multiprotein complex WINAC which interacts with vitamin D receptor via Williams syndrom transcription factor. Results demonstrate that WINAC dysfunction affects the Williams syndrome, and that the Williams syndrom therefore can be considered a chromatin-remodeling factor disease.

Japan, Causes of, Genetic aspects, Proteins, Cell research, Cytological research, Williams syndrome

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Inflammation and sex steroid receptors: A motif for change

Article Abstract:

The reversal of the inhibitory effects of sex hormone receptor antagonists by the proinflammatory cytokine interleukin-1 beta (IL-1beta) is discussed. Proinflammatory signals target adaptor protein TAB2 and switches repressed steroid hormone receptors into transcriptional activators.

Science & research, Care and treatment, Research, Interleukin-1, Homeostasis, Endocrine gland diseases, Endocrine diseases

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Nuclear receptors: a rendezvous for chromatin remodeling factors

Article Abstract:

This review examines the molecular mechanisms involved in the control of gene expression by the transcription factor, vitamin D receptor, of the nuclear receptors family. A novel ATP-dependent chromatin remodeling complex, WINAC, is implicated in the regulatory mechanisms.

Gene expression, Cell receptors, Structure-activity relationships (Biochemistry)

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