The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins

Article Abstract:

Phosphorylation of mitotic proteins on the Ser/Thr-Pro motifs is a significant factor in regulating mitotic progression. The necessary mitotic peptidyl-prolyl isomerase Pin1 regulates mitosis-specific phosphoproteins and binds them. In human cells and Xenopus extracts, Pin1 is involved directly with a subset of mitotic phosphoproteins on phosphorylated Ser/Thr-Pro patterns in a phosphorylation-dependent and mitosis-specific way.

Cell cycle, Mitosis, Phosphoproteins, Isomerases

---

Pin1 modulates RNA polymerase II activity during the transcription cycle

Article Abstract:

The roles played by Pin1 in modulating the RNA polymerase II (RNAP II) transcription are examined. Chromatin immunoprecipitation (ChIP) shows that the inhibition has reflected Pin1 activity during transcription initiation and not elongation, indicating that Pin1 modulated the C-terminal domain of RNAP II largest subunit (CTD) phosphorylation, and RNAP II activity, during an early stage of transcription cycle.

Chromatin, Genetic transcription, Transcription (Genetics)

---

Pin 1 modulates the structure and function of human RNA polymerase II

Article Abstract:

The influence of peptidyl-prolyl isomerase Pin1 on the phosphorylation status of the C-terminal domain (CTD) in vitro is shown by inhibiting the CTD phosphatase FCP1 and stimulating CTD phosphorylation by cdc2/cyclin B. thus, a significant role is played by Pin1 in regulating RNAP II CTD structure and function.

Influence, Cyclophilin, Genetic research, Properties, Structure

Similar abstracts:

• Abstracts: Identification, characterization, and in situ detection of a fruit-body-specific hydrophobin of Pleurotus ostreatus
• Abstracts: Genetic identification of a putative vinyl chloride reductase in Dehalococcoides sp. strain BAV1
• Abstracts: Pyridine-2,6-bis(thiocarboxylic acid) produced by Pseudomonas stutzeri KC reduces and precipitates selenium and tellurium oxyanions
• Abstracts: A most-probable-number assay for enumeration of infectious Cryptosporidium parvum oocysts. Use of cell culture to assess Cryptosporidium parvum survival rates in natural groundwaters and surface waters
• Abstracts: Peptide ligands that bind selectively to spores of Bacillus subtilis and closely related species. Species-specific peptide ligands for the detection of Bacillus anthracis spores

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.