The human p62 cDNA encodes Sam68 and not the RasGAP-associated p62 protein
Article Abstract:
The human cDNA with a structure analogous to DNA expressing p62 protein in other organisms was found to express a a protein with a structure similar to p62. This protein, Sam68, is also identified by antibodies that are specific for p62. However, they have different functions in the cell. Sam68 is involved in the interphase stage of mitosis, while p62 is typically associated with the RasGAP protein.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1996
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H2AX haploinsufficiency modifies genomic stability and tumor susceptibility
Article Abstract:
Research indicates that histone H2Ax plays a role in the genomic stability and radiation resistance. However, loss of a single H2AX allele or substitution of the serine phosphorylation sites in H2AX compromise the genomic integrity, leading to cancer susceptibility enhancement in the absence of tumor suppressor gene p53.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2003
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More than one way to skin a catenin
Article Abstract:
Research reveals that destruction of beta-catenin is mediated by two pathways, whose independent signals interfere in the regulation of beta-catenin. Data indicate that the pathways use different proteins, which recognize the N-terminal sequence of beta-catenin.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2001
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