The male-specific lethal-one (msl-1) gene of Drosophila melanogaster encodes a novel protein that associates with the X chromosome in males
Article Abstract:
The cloning and characterization of the msl-1 gene was reported. The gene was found to be associated with other chromosome sites in the male but not in polytene nuclei of the female. It is suggested that msl-1 is connected with chromatin modeling and transcription because of similarities to proteins involved in these processes. Three transcripts of the gene were found to be present in various life stages of D. melanogaster. The distribution of msl-1 was related to sex, staining being completely absent in the female.
Publication Name: Genetics
Subject: Biological sciences
ISSN: 0016-6731
Year: 1993
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Expression of Msl-2 causes assembly of dosage compensation regulators on the X chromosomes and female lethality in Drosophila
Article Abstract:
The ectopic expression of the male-specific lethal-2 (msl-2) gene in females causes an increase in the dosage compensation regulators, msl-1 and maleless, on the X chromosomes which decreases the viability and reproductive ability of the female Drosophila. The msl-2 contains many sex lethal protein binding sites and it is male specific although it is present in both males and females. The amount of the protein encoded by msl-2 is more in males than females.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 1995
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Global regulation of X chromosomal genes by the MSL complex in Drosophila melanogaster
Article Abstract:
RNA interference is used to deplete Male-Specific Lethal (MSL) complexes from male-like tissue culture cells. It is found that the primary role of the MSL complex is to up-regulate the male X chromosome.
Publication Name: Genes & Development
Subject: Biological sciences
ISSN: 0890-9369
Year: 2005
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