RNA interference is mediated by 21- and 22-nucleotide RNAs

Article Abstract:

RNA interference (RNAi) has been found to be mediated by 21- and 22-nucleotide RNAs by study in a Drosophila in vitro system. The RNAs are sequence-specific mediators of RNAi, with the short interfering RNAs generated by an RNase III-like processing reaction from long double-stranded RNA (dsRNA). Likely the direction of dsRNA processing determines whether the siRNA-protein complex can cleave sense or antisense target RNA.

Antisense DNA

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The neuron-specific RNA-binding protein ELAV regulates neuroglian alternative splicing in neurons and binds directly to its pre-mRNA

Article Abstract:

ELAV, the neuron-specific RNA-binding protein, has been found to regulate neuroglian alternative splicing in neurons, binding directly to its pre-mRNA. It is shown, using a minigene reporter, that the nrg transcript involves alternative inclusion of a 3'-terminal exon.

United States, Carrier proteins, Transport proteins, Neurons

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Tousled-like kinase functions with the chromatin assembly pathway regulating nuclear divisions

Article Abstract:

Research has been conducted on tousled-like kinases which phosphorylate the antisilencing function protein 1 involved in replication-dependent chromatin assembly. The authors have demonstrated that Drosophila antisilencing function protein is tousled-like kinases' phosphorylation target.

Switzerland, Analysis, Chromatin, Protein kinases, Phosphorylation, Genetic research, Gene silencing, DNA replication

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