The oncoprotein Bcl-3 directly transactivates through kappa-B motifs via association with DNA-binding p50B homodimers

Article Abstract:

The role of the oncoprotein Bcl-3, an l-kappa-B-related protein with ankyrin repeat motifs, in the development of B cell chronic lymphocytic leukemias was investigated. The results showed that Bcl-3 tightly associates with p50B homodimers, which are prototypical transcription factors that bind to kappa-B sites. The Bcl-3-p50B complex is tethered to DNA via the p50B homodimer, thus allowing Bcl-3 to transactivate directly. These results suggest a novel role for Bcl-3 distinct from that of l-kappa-B. The implications for tumorigenesis are discussed.

Genetic regulation, Genetic transcription, Transcription (Genetics)

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Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis

Article Abstract:

New blood vessels in the adult human being are produced through angiogenesis, a process by which new capillaries sprout from existing blood vessels. However, aside from its role in blood vessel production, angiogenesis also influences growth of solid tumors. Although as yet inconclusive, studies on cancer in transgenic mouse and humans indicate that tumors can be successful if they are able to control a switch that leads to angiogenesis.

Neovascularization

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The regulation of INK4/ARF in cancer and aging

Article Abstract:

A study is conducted to find the role of [p16.sup.INK4a], ARF and [p15.sup.INK4b] in cancer and aging. The data suggest that [p16.sup.INK4a] plays an important role in mammalian aging and a holistic understanding of these factors allows precise determination of how cells sense the earliest effects of carcinogenesis.

Research and Development in the Physical, Engineering, and Life Sciences, Science & research, Research and Testing Services, Cancer & Cell R&D, Aging, Cancer research, Cancer, Oncology, Experimental, Aging (Biology)

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