The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappa B that blocks TNFalpha-induced apoptosis

Article Abstract:

The survival-promoting Bcl-2 homolog Bfl-1/A1 is a direct transcription target for NF-kappa B. Bcl-2-family proteins are critical regulators of apoptotic response and bfl-1 gene expression depends on NF-kappa B activity. It can substitute for NF-kappa B to suppress TNF alpha-induced apoptosis. Activation of Bfl-1 may be the mechanism by which NF-kappa B functions in oncogenesis and helps cells to be resistant to anti-cancer therapy.

Cell death, Proteins, Genetic regulation, Genetic transcription, Transcription (Genetics), Cellular control mechanisms, Cell regulation, Carcinogenesis, HeLa cells

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pha-4, an HNF-3 homolog, specifies pharyngeal organ identity in Caenorhabditis elegans

Article Abstract:

Embryonic mechanisms integrate development among cells that are initially unrelated to each other to form complex organs. In building the pharynx for Caenorhabditis elegans, the pha-4 locus sets organ identity and encodes an HNF-3 homolog, a transcription-based mechanism, which results in cells being directed to form the nascent digestive tract.

Models, Homology (Biology), Embryology, Animal embryology, Pharynx

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The function of Xenopus Bloom's syndrome protein homolog (xBLM) in DNA replication

Article Abstract:

The Bloom's syndrome gene (BLM) homolog of the frog Xenopus laevis (xBLM) has been cloned. Antibodies to it were raised. It appears that Bloom's syndrome may result from defective DNA replication. protein homolog (xBLM) in DNA replication. The BLM is pivotal in the maintenance of genomic stability in somatic cells.

DNA, Xenopus

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