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The pancreatic beta cell heats up: UCP2 and insulin secretion in diabetes

Article Abstract:

The authors review the publications on the pancreatic beta cell which responds to small changes in the blood glucose concentration via insulin secretion regulation. The topics of interest include the uncoupling glucose metabolism from ATP generation and its effect on the beta cell ability to secrete insulin in response to glucose.

Author: Semenkovich, Clay F., Polonsky, Kenneth S.
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2001
Diabetes, Diabetes mellitus, Secretion, Pancreatic beta cells

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New perspectives into the molecular pathogenesis and treatment of Type 2 diabetes

Article Abstract:

The authors review the publications on diabetes caused by the improper regulation of carbohydrate and lipid metabolism by insulin. The insights into the underlying pathophysiology and genetics of Type 2 diabetes and the prospects for the therapeutic intervention have been explored and discussed.

Author: Saltiel, Alan R.
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2001
Statistical Data Included, Type 2 diabetes, Carbohydrates, Lipid metabolism, Pathogenic microorganisms, Physiology, Pathological, Pathological physiology

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Muscle or fat? Rho bridges of GAP

Article Abstract:

The author discusses the publication on mesenchymal stem cells. The topics of interest include the role of Rho GTPase in cellular fate which promote myogenesis and inhibits adipogenesis.

Author: Saltiel, Alan R.
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2003
Science & research, Research, Genetic aspects, Growth, Growth factors, Stem cells, Chemical inhibitors, Myogenesis, Company growth, Guanosine triphosphatase

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Subjects list: United States, Analysis, Causes of, Physiological aspects, Cell research, Cytological research, Insulin
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