The polyadendylation factor CPSF-73 is involved in histone-pre-mRNA processing

Article Abstract:

UV crosslinking studies were carried out using both the complete RNA substrate and the downstream cleavage product, each containing a single radioactive phosphate and a phosphorothiolate modification at the cleavage site. It is suggested that cleavage/polyadenylation specificity factor-73 (CPSF-73) is both the endonuclease and 5',3' exonuclease in histone-pre-mRNA processing and reveal an evolutionary link between 3' end formation of histone mRNAs and polyadenylated mRNAs.

RNA processing, Ribonucleoproteins

---

Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases

Article Abstract:

The JmjC domain-containing protein JMJD2A reversed trimethylated H3-K9/K36 trimethylation levels in cultured cells. The findings that this family of demethylases generates different methylated states at the same lysine residue provides a mechanism for fine-tuning histone methylation.

Lysine

---

Histone deimination antagonizes arginine methylation

Article Abstract:

A process called deimination that converts histone arginine to citrulline and antagonizes arginine methylation is discussed. The results show that deimination is a unique mechanism for antagonizing the transcriptional induction through arginine methylation.

Methods, Arginine, Chemical properties

Similar abstracts:

• Abstracts: The F box protein Dsg1/Mdm30 is a transcriptional coactivator that stimulates Gal4 turnover and cotranscriptional mRNA processing
• Abstracts: The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination. Unraveling V(D)J recombination: insights into gene regulation
• Abstracts: Redox regulation facilitates optimal peptide selection by MHC class I during antigen processing. Mechanisms of conformational change for a replicative hexameric helicase of SV40 large tumor antigen
• Abstracts: The ubiquitin ligase Rnf6 regulates local LIM kinase 1 levels in axonal growth cones. The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans
• Abstracts: Control of the assembly of ATP- and ADP-Actin by formins and profilin. The beta-thymosin/WH2 domain: structural basis for the switch from inhibition to promotion of actin assembly

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.